지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 499 - 508 (10page)
이용수
초록· 키워드
오류제보하기
Objectives : Skeletal muscle atrophy occurs in response to a variety of conditions. The unloading to muscle occurs clinically in limb immobilization, bed rest, spinal cord injury and peripheral nerve damage, resulting in significant loss of muscle mass and force production. Muscle disuse is accompanied by an increase in apoptotic signaling, which mediates some of the responses to unloading in the muscle. In this study we tested the hypothesis that Daeyeoung-jeon extract would improve muscle recovery after reloading following disuse. Method : Twenty young male Sprague-Dawley rats were used for the studies. The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. No intervention was performed on the right leg and used as intact region. The Rats in Daeyeoung-jeon treated group (DYJ) were orally administrated Daeyeoung-jeon water extract, and rats of Control group were given with saline only. After 2 weeks of immobilization, all animals were sacrificed, and the whole gastrocnemius muscles were dissected from both legs. The morphology of right and left gastrocnemius muscles in both DYJ and Control groups were assessed by hematoxylin and eosin staining. Moreover, to investigate the immobilization-induced muscular apoptosis, the immunohistochemical analysis of Bax and Bcl-2 was carried out. Results : Daeyeoung-jeon represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group. The treatment with Daeyeoung-jeon extract significantly reduced the immunoreactivity of BAX and increased the immunoreactivity of Bcl-2 in gastrocnemius muscle compared with Control group. Conclusion : Daeyeoung-jeon has protective effects against immobilization-induced muscle atrophy by regulating the activities of apoptosis-associated BAX/Bcl-2 proteins in gastrocnemius muscle.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alway SE / 2015 / Green tea extract attenuates muscle loss and improves muscle function during disuse, but fails to improve muscle recovery following unloading in aged rats / J Appl Physiol 118(3):319~330
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Powers SK / 2012 / Oxidative stress and disuse muscle atrophy: cause or consequence? / Curr Opin Clin Nutr Metab Care 15(3):240~245
Alway SE / 2008 / Nuclear apoptosis contributes to sarcopenia / Exerc Sport Sci Rev 36(2):51~57
Siu PM / 2005 / Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading / Am J Physiol Cell Physiol 288(2):338~349
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Powers SK / 2012 / Oxidative stress and disuse muscle atrophy: cause or consequence? / Curr Opin Clin Nutr Metab Care 15(3):240~245
Alway SE / 2008 / Nuclear apoptosis contributes to sarcopenia / Exerc Sport Sci Rev 36(2):51~57
Siu PM / 2005 / Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading / Am J Physiol Cell Physiol 288(2):338~349
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