지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Objectives Disuse muscle atrophy occurs in response to pathologies such as joint immobilization, inactivity or bed rest. Muscle disuse is accompanied by an increase in apoptotic signaling, which mediates some of the responses to unloading in the muscle. GB34 (Yanglingquan) is a acupuncture point on the lower leg and one of the most frequently used points in various skeletomuscular diseases. In this study, the hypothesis that the acupuncture at GB34 could attenuate immobilization-induced skeletal muscle atrophy was tested. Methods The left hindlimb immobilization was performed with casting tape in both GB34 group (n=10) and Control group (n=10). The rats in GB34 group were daily treated with acupuncture at GB34. After 2 weeks of immobilization, the morphology of right and left gastrocnemius muscles in both GB34 and Control groups were assessed by hematoxylin and eosin staining. To investigate the immobilization-induced muscular apoptosis, the immunohistochemical analysis of Bax and Bcl-2 was carried out. Results GB34 group represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group. The acupuncture at GB34 significantly reduced the immunoreactivity of BAX and increased the immunoreactivity of Bcl-2 in gastrocnemius muscle compared with Control group. Conclusions These results suggest that the acupuncture at GB34 has protective effects against immobilization-induced muscle atrophy by regulating the activities of apoptosis-associated BAX/Bcl-2 proteins in gastrocnemius muscle.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Wall BT / 2013 / Nutritional strategies to attenuate muscle disuse atrophy / Nutr Rev 71(4):195~208
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Valenzuela PL / 2018 / Physical strategies to prevent disuse-induced functional decline in the elderly / Ageing Res Rev 47(1):80~88
Pileggi CA / 2018 / Exercise recovery increases skeletal muscle H2O2emission and mitochondrial respiratory capacity following two-weeks of limb immobilization / Free Radic Biol Med 124(1):241~248
Kozakowska M / 2015 / The role of oxidative stress in skeletal muscle injury and regeneration : focus on antioxidant enzymes / J Muscle Res Cell Motil 36(6):377~393
Wall BT / 2013 / Skeletal muscle atrophy during short-term disuse : implications for age-related sarcopenia / Ageing Res Rev 12(4):898~906
Valenzuela PL / 2018 / Physical strategies to prevent disuse-induced functional decline in the elderly / Ageing Res Rev 47(1):80~88
Pileggi CA / 2018 / Exercise recovery increases skeletal muscle H2O2emission and mitochondrial respiratory capacity following two-weeks of limb immobilization / Free Radic Biol Med 124(1):241~248
Kozakowska M / 2015 / The role of oxidative stress in skeletal muscle injury and regeneration : focus on antioxidant enzymes / J Muscle Res Cell Motil 36(6):377~393
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