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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 175 - 175 (1page)
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In this study, the inhibitory effect of hot-water extract of GB (HW-GB) on inflammation of LPS-stimulated Raw 264.7 macrophages and alloxan-induced diabetes was investigated. In the anti-inflammatory activity, treatment with HW-GB significantly inhibited the production of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor (TNF-α) and IL-6 from LPS-stimulated Raw 264.7 macrophages in a dose-dependent manner. Treatment of HW-GB also showed the expression of mRNAs of iNOS synthase, TNF-α and IL-6 in RT-PCR analysis. Furthermore, this extract of GB was shown to inhibit LPS-induced inflammation in RAW 264.7 macrophages via down-regulation of activation of MAPKs such as ERK, JNK and p38. For type 1 diabetes experiment, HW-GB was administered orally for 5 days before alloxan injec^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10617970');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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