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논문 기본 정보

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Kim Jeong-Min (Korea Centers for Disease Control and Prevention) Kim Heui Man (Korea Centers for Disease Control and Prevention) Lee Eun Jung (Korea Centers for Disease Control and Prevention) Jo Hye Jun (Korea Centers for Disease Control and Prevention) Yoon Youngsil (Korea Centers for Disease Control and Prevention) Lee Nam-Joo (Korea Centers for Disease Control and Prevention) Son Junseock (Korea Centers for Disease Control and Prevention) Lee Ye-Ji (Korea Centers for Disease Control and Prevention) Kim Mi Seon (Korea Centers for Disease Control and Prevention) Lee Yong-Pyo (Korea Centers for Disease Control and Prevention) Chae Su-Jin (Korea Centers for Disease Control and Prevention) Park Kye Ryeong (Korea Centers for Disease Control and Prevention) Cho Seung-Rye (Korea Centers for Disease Control and Prevention) Park Sehee (Korea Centers for Disease Control and Prevention) Kim Su Jin (Korea Centers for Disease Control and Prevention) Wang Eunbyeol (Korea Centers for Disease Control and Prevention) Woo SangHee (Korea Centers for Disease Control and Prevention) Lim Aram (Korea Centers for Disease Control and Prevention) Park Su-Jin (Korea Centers for Disease Control and Prevention) Jang Jun-Hyeong (Korea Centers for Disease Control and Prevention) Chung Yoon-Seok (Korea Centers for Disease Control and Prevention) Chin Bum Sik (National Medical Center) Lee Jin-Soo (Inha University School of Medicine) Lim Duko (Gyeonggi Provincial Medical Center Ansung Hospital) Han Myung-Guk (Korea Centers for Disease Control and Prevention) Yoo Cheon Kwon (Korea Centers for Disease Control and Prevention)
저널정보
질병관리본부 Osong Public Health and Research Persptectives Osong Public Health and Research Persptectives Vol.11 No.3
발행연도
2020.1
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112 - 117 (6page)

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Objectives Coronavirus Disease-19 (COVID-19) is a respiratory infection characterized by the main symptoms of pneumonia and fever. It is caused by the novel coronavirus severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), which is known to spread via respiratory droplets. We aimed to determine the rate and likelihood of SARS-CoV-2 transmission from COVID-19 patients through non-respiratory routes. Methods Serum, urine, and stool samples were collected from 74 hospitalized patients diagnosed with COVID-19 based on the detection of SARS-CoV-2 in respiratory samples. The SARS-CoV-2 RNA genome was extracted from each specimen and real-time reverse transcription polymerase chain reaction performed. CaCo-2 cells were inoculated with the specimens containing the SARS-COV-2 genome, and subcultured for virus isolation. After culturing, viral replication in the cell supernatant was assessed. Results Of the samples collected from 74 COVID-19 patients, SARS-CoV-2 was detected in 15 serum, urine, or stool samples. The virus detection rate in the serum, urine, and stool samples were 2.8% (9/323), 0.8% (2/247), and 10.1% (13/129), and the mean viral load was 1,210 ± 1,861, 79 ± 30, and 3,176 ± 7,208 copy/µL, respectively. However, the SARS-CoV-2 was not isolated by the culture method from the samples that tested positive for the SARS-CoV-2 gene. Conclusion While the virus remained detectable in the respiratory samples of COVID-19 patients for several days after hospitalization, its detection in the serum, urine, and stool samples was intermittent. Since the virus could not be isolated from the SARS-COV-2-positive samples, the risk of viral transmission via stool and urine is expected to be low.
#COVID-19 #SARS-CoV-2 #transmission

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참고문헌 신청
Zhu N / 2020 / A novel coronavirus from patients with pneumonia in China, 2019 / N Engl J Med 382(8):727~733 google schola Huang C / 2020 / Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / Lancet 395:497~506 google schola Eu Suk Kim / 2020 / Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19 / Journal of Korean Medical Science 35(13):1~12 dbpia Jin Y / 2020 / Virology, epidemiology, pathogenesis, and control of COVID-19 / Viruses 12(4):E372 google schola Weiss SR / 2011 / Coronavirus pathogenesis / Adv Virus Res 81:85~164 google schola

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