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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 17 - 27 (11page)
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초록· 키워드
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4+ and CD8+ T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.
목차
ABSTRACT
INTRODUCTION
SARS-CoV-2-SPECIFIC T-CELL RESPONSES IN CONVALESCENTS
SARS-CoV-2-SPECIFIC T-CELL RESPONSES DURINGACUTE INFECTION
SEVERITY OF INFECTION AND SARS-CoV-2-SPECIFICT-CELL RESPONSES
SARS-CoV-2-REACTIVE T-CELL RESPONSES INUNEXPOSED INDIVIDUALS
VACCINE-INDUCED T-CELL RESPONSES
PERSPECTIVES
REFERENCES
참고문헌 (44)
참고문헌 신청
Huang C / 2020 / Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / Lancet 395:497~506
Lee JS / 2020 / Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 / Sci Immunol 5:eabd1554
Merad M / 2020 / Pathological inflammation in patients with COVID-19 : a key role for monocytes and macrophages / Nat Rev Immunol 20:355~362
Petersen E / 2020 / Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics / Lancet Infect Dis 20:e238~e244
Lionel Piroth / 2021 / Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study / The Lancet Respiratory Medicine 9(3):251~259
Lee JS / 2020 / Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 / Sci Immunol 5:eabd1554
Merad M / 2020 / Pathological inflammation in patients with COVID-19 : a key role for monocytes and macrophages / Nat Rev Immunol 20:355~362
Petersen E / 2020 / Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics / Lancet Infect Dis 20:e238~e244
Lionel Piroth / 2021 / Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study / The Lancet Respiratory Medicine 9(3):251~259
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